Fuller's, the brewer whose beers include London Pride, is to sell its entire drinks business to Japan's biggest brewer Asahi.
The company said the £250m deal would preserve the Griffin Brewery in Chiswick, west London, where beer has been brewed since 1654.
Fuller's will now focus on its hotels and pubs business, which generates most of its profits.
Asahi is the owner of the Peroni and Grolsch brands.
Fuller's said the deal - which also includes cider and soft drinks brand Cornish Orchards and craft cask brewer Dark Star - was due to "structural changes to the beer industry".